Uruguay's Edinson Cavani scored early and fellow striker Luis Suarez converted a second-half penalty, his fourth in three games for his country, because they beat Colombia 3-0 in Friday's World Cup qualifier.
Cavani got the opener in the fifth minute after Nahitan Nandez had done the hard work in midfield by robbing the ball and setting him up to fire home a minimal right-foot shot.
Suarez then put into the lead nine minutes into the second period when he scored from the location after Jeison Murillo brought down Rodrigo Bentancur.
Darwin Nunez completed the scoring after 73 minutes when his pot shot from 25 metres beat the diving David Ospina.
Yerry Mina was sent off for Colombia after a second yellow card in the ultimate minute of the overall game to complete a miserable afternoon for the home side.
Suarez's goal was his 63rd international strike and came after he scored twice from the penalty spot in Uruguay's 4-2 loss to Ecuador and once in their 2-1 win over Chile within their opening qualifier last month.
The victory takes Uruguay to six points after three games, while Colombia, who beat Venezuela and drew away to Chile in their first two games, have four.
The most notable four sides in the 10-team South American group qualify automatically for the Qatar 2022 finals and the fifth-placed team get into an inter-regional playoff.
Uruguay now travel home to face Brazil on Tuesday when Colombia will be away to Ecuador.